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ONESSIP ADULT NIGHTTIME SEVERE COLD AND FLU 650 mg/15mL, 20 mg/15mL, 12.5 mg/15mL, 10 mg/15mL solution by MEDWISE LIFESCIENCES INC.
ONESSIP ADULT NIGHTTIME SEVERE COLD AND FLU, 650 mg/15mL, 20 mg/15mL, 12.5 mg/15mL, 10 mg/15mL, solution Drug class: Antihistamine; Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist; alpha-1 Adrenergic Agonist. Available over the counter. Listed by MEDWISE LIFESCIENCES INC..
Over the counter

ONESSIP ADULT NIGHTTIME SEVERE COLD AND FLU

Acetaminophen, Dextromethorphan HBr, Doxylamine Succinate, Phenylephrine HCI

Listed by MEDWISE LIFESCIENCES INC.

Strength
650 mg/15mL, 20 mg/15mL, 12.5 mg/15mL, 10 mg/…
Form
Solution
Route
Oral
Class
Antihistamine; Sigma-1 Agonist; Uncompetitive…

What it contains

  • Phenylephrine Hydrochloride 650 mg/15mL
  • Dextromethorphan Hydrobromide 20 mg/15mL
  • Acetaminophen 12.5 mg/15mL
  • Doxylamine Succinate 10 mg/15mL

This is a combination product. It is not interchangeable with a single-ingredient medicine containing only one of these.

FDA record

Dosage form Solution
Route Oral
Drug class Antihistamine; Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist; alpha-1 Adrenergic Agonist
Approval route OTC monograph
NDC code 87078-872
FDA application M012
RxNorm concept 2733907
Package sizes listed 1
Marketed since January 2026

Other products containing Phenylephrine

See all

Same active ingredient, different manufacturer, strength or form. Products matching on both ingredient and strength are usually interchangeable — but confirm before switching, especially with modified-release forms.

4 Way Fast Acting

Phenylephrine hydrochloride

Strength
10 mg/mL
Form
Spray
Class
alpha-1 Adrenergic Agonist
OTC

Haleon US Holdings LLC

Not stocked by us — reference only

ACTIFED

Phenylephrine hydrochloride

Strength
5 mg/1
Form
Tablet
Class
alpha-1 Adrenergic Agonist
OTC

Belmora LLC

Not stocked by us — reference only

Information only, not medical advice. Nothing on this page indicates that a medication is safe or suitable for you. Speak to a prescriber or pharmacist before starting, stopping or switching any medicine.